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目的探讨缺锌对余杭地区儿童体内T淋巴细胞及相关细胞因子的影响。方法选择当地缺锌(血锌<75μg/L)儿童43例(缺锌组)和健康儿童40例(健康对照组),观察身高和体重。采用ELISA法检测血清中γ干扰素(IFN-γ)、白细胞介素-2(IL-2)和白细胞介素-4(IL-4)水平;采用流式细胞术检测CD3+T细胞和CD4+T细胞。结果缺锌组儿童平均身高和体重均低于健康对照组;缺锌组儿童血清中IFN-γ、IL-2和IL-4和体内CD3+T细胞和CD4+T细胞水平均显著低于健康对照组(P<0.05)。结论锌缺乏可影响儿童细胞免疫功能。
Objective To explore the effect of zinc deficiency on T lymphocytes and related cytokines in children in Yuhang area. Methods Forty-three children with zinc deficiency (zinc deficiency <75μg / L) and 40 healthy children (healthy control group) were selected to observe height and weight. Serum levels of IFN-γ, IL-2 and IL-4 were detected by ELISA. Flow cytometry was used to detect the levels of CD3 + T cells and CD4 + T cells. Results The average height and weight of children in the zinc deficient group were lower than those in the healthy control group. The serum levels of IFN-γ, IL-2 and IL-4, CD3 + T cells and CD4 + T cells in the zinc-deficient group were significantly lower than those in the healthy group Control group (P <0.05). Conclusion Zinc deficiency can affect children’s cellular immune function.