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目的 :探讨宫颈癌患者血清、组织硒与白细胞介素 2受体 (SIL 2R)、肿瘤坏死因子 a(TNF a)的相关性。方法 :用VI 2 0 0 0型原子荧光光度计测定了 15 0例宫颈癌患者 ,45例宫颈良性疾患及 5 0例健康人血清及组织中的硒 ,同时对 75例宫颈癌患者 ,45例良性疾患及健康人血清SIL 2R、TNF a进行了检测。结果 :宫颈癌患者血清及组织中硒含量 0 .80± 0 .2 7nmol/ml,2 .98± 1.78nmol/g明显低于宫颈良性疾患 0 .90± 0 .14nmol/ml,3.75± 1.80nmol/g及健康人 1.0 8± 0 .2 2nmol/ml和正常组织 4.32± 2 .0 8nmol/g(分别P <0 .0 1～P <0 .0 0 1) ,宫颈良性疾患血清与健康人比较有显著性差异 (P <0 .0 5 ) ;宫颈癌患者血清SIL 2R水平 349.6± 191.7U/ml,TNF a水平 389.8± 2 43.7pg/ml明显高于宫颈良性疾患 2 41.2± 135 .4U/ml,2 45 .8± 115 .4pg/ml和健康人 15 3 .4± 5 8.6U/ml,198.4± 96 .5pg/ml(分别P <0 .0 5～P <0 .0 0 1) ;直线相关分析血清硒 ,组织硒含量与血清SIL 2R ,TNF a呈明显负相关 (分别r =- 0 .395 ,r=-0 .387,r=- 0 .2 95 )。结论 :对宫颈癌患者补硒 ,可能降低SIL 2R含量 ,从而使IL 2发挥其正常生物学效应 ,提高机体自身抗癌能力 ,可能是一种合理、有效的辅助治疗手段
Objective: To investigate the correlation between serum selenium and interleukin 2 receptor (SIL 2R) and tumor necrosis factor a (TNFa) in patients with cervical cancer. Methods: Selenium in 150 cases of cervical cancer, 45 cases of cervical benign disease and 50 cases of healthy human serum and tissues were determined by VI 20 000 atomic fluorescence spectrophotometer. Meanwhile, 75 cases of cervical cancer, 45 cases of cervical cancer Benign disease and healthy people serum SIL 2R, TNF a were detected. Results: The selenium content in serum and tissues of cervical cancer patients was significantly lower than that of benign cervical diseases (0 .80 ± 0.27nmol / ml, 2.98 ± 1.78nmol / g, 0.90 ± 0.14nmol / ml, 3.75 ± 1.80nmol / g and healthy people 1.08 ± 0.22nmol / ml and normal tissue 4.32 ± 2.08nmol / g (P <0.01 ~ P <0.01, respectively), cervical benign disease serum and healthy people (P <0.05). The serum level of SIL 2R in cervical cancer patients was 349.6 ± 191.7U / ml, the level of TNFa was 389.8 ± 2 43.7pg / ml, which was significantly higher than that of benign cervical diseases 2 41.2 ± 135.4U / ml, 2 45 .8 ± 115 .4 pg / ml and healthy persons 15 3 .4 ± 5 8.6U / ml, 198.4 ± 96 .5 pg / ml (P <0 05 ~ P <0 01 ). The linear correlation analysis of serum selenium, tissue selenium content and serum SIL 2R, TNFα was negatively correlated (r = -0.3395, r = -0.387, r = - 0.225, respectively). Conclusion: Selenium in patients with cervical cancer may reduce SIL 2R content, so that IL 2 play its normal biological effects and improve the body’s own anti-cancer ability may be a reasonable and effective adjuvant therapy