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目的:了解反复自然流产(RSA)患者的心理健康状况及机体免疫状态。方法:采用症状自评量表(SCL-90)对2007年8月～2011年10月就诊于新疆医科大学第一附属医院及新疆自治区人民医院142例RSA患者和102例正常妇女进行心理状况调查,并用双抗体夹心酶联免疫吸附法检测其Th1(IFN-γ)和Th2(IL-4)细胞因子水平。结果:RSA患者SCL-90自评总分、总均分、抑郁、人际关系敏感因子均分高于正常对照组(P<0.05),RSA患者IFN-γ水平高于正常对照组(P<0.05),IL-4水平低于正常对照组(P<0.05)。结论:反复自然流产可以影响妇女的正常心理活动,较差的心理状态干扰机体免疫功能,应该对其进行适当的心理干预。
Objective: To understand the mental health status and immune status of patients with recurrent spontaneous abortion (RSA). Methods: A total of 142 RSA patients and 102 normal women in the First Affiliated Hospital of Xinjiang Medical University and People’s Hospital of Xinjiang Uygur Autonomous Region from August 2007 to October 2011 were investigated with the Symptom Checklist-90 (SCL-90) , And the levels of Th1 (IFN-γ) and Th2 (IL-4) cytokines were detected by double antibody sandwich enzyme-linked immunosorbent assay. Results: The scores of SCL-90 self-rated total score, total score, depression and interpersonal sensitivity in RSA patients were significantly higher than those in normal controls (P <0.05), and those in RSA patients were higher than those in normal controls (P <0.05) ), IL-4 levels were lower than the normal control group (P <0.05). Conclusions: Repeated spontaneous abortion can affect the normal psychological activities of women. Poor mental state interferes with the immune function of the body and should be appropriately psychological intervention.