Sodium valproate (VPA) is an anti-epileptic drug which was until now administered to children as drinkable or injectable form. A new galenic form of this compound has been developed asmicrogranules with prolonged release (Micropakine LP; MPK). This new galenic form of VPA allows a greater stability of the plasmatic rates, thus limiting the risk of amount-dependent adverse effects at the time of the peaks, and of less effectiveness at the time of the fall of the circulating rates. The main objective of this study was to evaluate the acceptability of the new galenic form of VPA, in monotherapy, for epileptic children with ≥ 3 years old. The evaluation was performed at day (D)90 by the patients using a hedonic visual scale. The secondary objectives were to evaluate the acceptability by the parents, the treatment compliance, the percentage of patients free of seizure at D 90, and the tolerance. Finally, the authors compared all these data to those recovered at the baseline in patients already treated by the previous drinkable VPA. A total of 307 patients were involved by 76 hospital neuropediatric physicians. The population was constituted by 110 children < 5 years old and 197 children from 5 to 14 years old. MPK was well accepted for total population at D 90 (< 5 years old: 83.3% ; ≥ 5 years old: 80% ). For patients previously treated by drinkable form of VPA (N = 199), MPK was significantly better accepted than the drinkable form at D1 (< 5 years, P = 0.0189; > 5 years, P < 0.0001). Less difficulties were experienced by the parents to administrate MPK when compared to the drinkable form (P < 0.001), mainly due to his neutral taste. Patients free of seizure at D 90 were 77% 70,3; 82,5 . Specially, fewer epileptic seizures were evidenced for all children previously treated at D1 by drinkable form of VPA. The treatment was well respected by the patients, which were compliant in 80% of the cases. The adherence to treatment was good since the treatment compliance was 87% . MPK was well tolerated. Conclusion. -MPK in the microgranule form significantly improves the treatment acceptability with a good tolerance. Two daily intakes and neutral taste are two major advantages to favour the compliance in children, thus contributing to the efficacy of the antiepileptic treatment. A new galenic form of this compound has been developed as microgranules with prolonged release (Micropakine® LP; MPK). This new galenic form (VPA) is an anti-epileptic drug which was until now administered to children as drinkable or injectable form. of VPA allows a greater stability of the plasmatic rates, thereby limiting the risk of amount-dependent adverse effects at the time of the peaks, and of less effectiveness at the time of the fall of the circulating rates. The main objective of this study was to evaluate the acceptability of the new galenic form of VPA, in monotherapy, for epileptic children with ≥ 3 years old. The evaluation was performed at day (D) 90 by the patients using a hedonic visual scale. The secondary objectives were to evaluate the acceptability by the parents, the treatment compliance, the percentage of patients free of seizure at D 90, and the tolerance. Finally, the authors all all these data to those recovered at the baseline in patients already treated by the previous drinkable VPA. A total of 307 patients were involved by 76 hospital neuropediatric physicians. The population was constructed by 110 children <5 years old and 197 children from 5 to 14 years old. For patients previously treated by drinkable form of VPA (N = 199), MPK was significantly better accepted than the drinkable form at D1 (<5 years (<5 years old: 83.3%; , P = 0.0189;> 5 years, P <0.0001). Less difficulties were experienced by the parents to administrate MPK when compared to the drinkable form (P <0.001), mainly due to his neutral taste. Patients free of seizure at D 90 were 77% 70,3; 82,5. Specially, fewer epileptic seizures were evidenced for all children previously treated at D1 by drinkable form of VPA. The treatment was well respected by the patients, which were compliant in 80% of the cases. The adherence to treatment was good since the treatment compliance wa s 87%MPK was well tolerated. Conclusion. -MPK in the microgranule form significantly improves the treatment acceptability with a good tolerance. Two daily intakes and neutral taste are two major advantages to favor the compliance in children, thus contributing to the efficacy of the antiepileptic treatment .