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目的:探讨多次妊娠Rh阴性女性接受Rh阳性亲属活体供肾移植的可行性及疗效。方法:回顾性分析1例多次妊娠Rh阴性女性受者的临床资料,结合相关文献分析总结其接受Rh阳性亲属活体供肾移植后,近期可能发生的不良反应以及对移植物存活的影响。结果:受者术后已存活5个多月,肾功能良好,未见急性排斥反应发生,抗RhD抗体阴性。术后95天并发巨细胞病毒肺炎,经更昔洛韦治疗后痊愈。结论:Rh阳性亲属供肾经过充分灌洗,可移植给Rh阴性女性受者,短期效果良好,长期肾存活有待继续观察。
Objective: To investigate the feasibility and efficacy of multiple pregnancy Rh-negative women receiving Rh-positive relatives living donor kidney transplantation. Methods: A retrospective analysis of one case of Rh-negative women with multiple pregnancy clinical data, combined with relevant literature analysis of its acceptance of Rh-positive relatives living donor kidney transplantation, the recent possible adverse reactions and graft survival. Results: The recipients survived for more than 5 months after surgery and had good renal function. No acute rejection occurred and anti-RhD antibodies were negative. 95 days after cytomegalovirus pneumonia complicated by ganciclovir treatment recovered. CONCLUSION: Rh-positive relatives can be transplanted to Rh-negative female recipients after sufficient lavage. The short-term results are good and long-term renal survival remains to be observed.