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目的研究淋巴细胞主动免疫疗法联合补肾调冲中药治疗复发性流产患者的临床疗效。方法将2014年1月至2015年12月180例复发性流产患者,按治疗方式分为治疗组(n=51)、对照1组(n=58)和对照2组(n=54),脱落及治疗中剔除患者17例。治疗组给予淋巴细胞主动免疫疗法联合补肾调冲中药及黄体支持;对照1组给予补肾调冲中药和黄体支持;对照2组仅给予黄体支持治疗。计算治疗组封闭抗体转阳率,通过比较三个组别的妊娠成功率和活产率,评价淋巴细胞主动免疫疗法联合补肾调冲中药治疗复发性流产患者的临床疗效。结果治疗组51例患者,第一疗程转阳率58.82%,第二疗程转阳率80.95%,累计转阳率92.16%。治疗组、对照1组和对照2组妊娠成功率分别为90.02%、77.59%和66.67%。与对照1组和对照2组相比,治疗组妊娠成功率显著增加,差异有统计学意义(P<0.05)。随访产后3个月,三组胎儿存活率分别为100.00%、91.18%和94.74%,三组比较差异无统计学意义(P>0.05)。结论冻存淋巴细胞免疫疗法联合补肾调冲中药治疗复发性流产可明显提高治疗妊娠率,胎儿存活率高,未见明显不良反应,母儿安全性良好。
Objective To study the clinical efficacy of active immunotherapy with lymphocytes combined with tonifying kidney and regulating traditional Chinese medicine in patients with recurrent spontaneous abortion. Methods 180 patients with recurrent spontaneous abortion from January 2014 to December 2015 were divided into treatment group (n = 51), control group 1 (n = 58) and control group 2 (n = 54) 17 cases were excluded from the treatment. The treatment group was given active immunotherapy of lymphocytes combined with tonifying kidney Chinese medicine and luteal support; the control group 1 was given Bushen tiaozhong Chinese medicine and luteal support; the control group 2 was only given luteal support treatment. The positive rate of blocking antibody in treatment group was calculated. The success rate of pregnancy and live birth rate in three groups were compared to evaluate the clinical effect of active immune therapy combined with Bushen Taizhong Chinese medicine in treating recurrent spontaneous abortion. Results The treatment group 51 patients, the first course of treatment turn positive rate of 58.82%, the second course of conversion positive rate of 80.95%, the cumulative positive rate of 92.16%. The pregnancy success rates in the treatment group, control group 1 and control group 2 were 90.02%, 77.59% and 66.67%, respectively. Compared with the control group 1 and control group 2, the success rate of pregnancy in treatment group increased significantly, the difference was statistically significant (P <0.05). Three months after delivery, the survival rates of the three groups were 100.00%, 91.18% and 94.74% respectively. There was no significant difference between the three groups (P> 0.05). Conclusion Cryopreserved lymphocyte immunotherapy combined with Bushen Tiaochong Chinese medicine treatment of recurrent spontaneous abortion can significantly improve the treatment of pregnancy rate, high fetal survival rate, no obvious adverse reactions, maternal and child safety is good.