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采用百日咳菌液右侧颈内动脉注射造成家兔急性感染性脑水肿（ＢＥ），测定不同时间脑组织水、钙、钙调素（ＣａＭ）含量，注射菌液后１ｈ，右侧脑组织水、钙含量均已明显增高（Ｐ＜０．０１），脑组织ＣａＭ含量也相应增高，注射菌液后２ｈ，其含量较对照组差异具有显著性意义（Ｐ＜０．０５），ＢＥ的发展与脑组织钙与ＣａＭ变化均呈正相关（ｒ＝０．８９０２，ｒ＝０．７９２５，Ｐ＜０．０１）。结果提示：脑组织钙聚积和ＣａＭ活性异常增高与感染性ＢＥ发病的关系密切。
Acute infectious brain edema (BE) was induced in rabbits by intraperitoneal injection of pertussis bacilli on the right side. The levels of water, calcium and calmodulin (CaM) in brain tissue were measured at different time points. (P <0.01). The content of CaM in brain tissue increased correspondingly. The content of CaM in brain tissue was significantly higher than that in control group at 2h There was a positive correlation between calcium and CaM in brain tissue (r = 0.8902, r = 0.7925, P <0.01). The results suggest that: calcium accumulation in brain tissue and abnormal increase in CaM activity is closely related to the onset of infectious BE.