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目的:了解再生障碍性贫血(aplastic anemia,AA)、骨髓增生异常综合征(marrow mesenchymal stem cells,MDS)患者骨髓间充质干细胞(marrow mesenchymal stem cells,MSCs)白介素-6(interleukin-6,IL-6)的表达,并分析其意义。方法:用半定量RT-PCR方法检测AA和MDS患者MSCs IL-6 mRNA的表达水平。结果:AA患者MSCs IL-6的表达明显低于MDS组和正常对照组,P<0.05;MDS患者和正常对照组之间IL-6的表达无明显差异,P>0.05。结论:AA患者MSCs IL-6的表达存在明显异常,这可能与AA的发病有一定的关系。
Objective: To investigate the expression of interleukin-6 (IL) in bone marrow mesenchymal stem cells (MSCs) of patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS) -6) expression, and analyze its significance. Methods: Semi-quantitative RT-PCR was used to detect the expression of IL-6 mRNA in MSCs from patients with AA and MDS. Results: The expression of IL-6 in MSCs was significantly lower in AA patients than that in MDS patients and normal controls (P <0.05). There was no significant difference in IL-6 expression between MS patients and normal controls (P> 0.05). Conclusion: The expression of IL-6 in MSCs is obviously abnormal in patients with AA, which may be related to the pathogenesis of AA.