目的　探讨在产褥期末放置两种载铜活性宫内节育器 (MLcu 375IUD和Tcu 2 2 0CIUD)的避孕效果、可行性和可接受性。方法　采用前瞻性随机、临床对比研究方法 ,粗累积事件率、净累积继续使用率采用Lifetable方法 ,出血类型分析采用 90d参考期统计方法。结果　在产褥期末放置两种载铜活性宫内节育器无子宫穿孔、无感染、无放置后大出血。两种宫内节育器放置后不良反应低 ,3、6、9个月出血发生率MLcu 375IUD均低于Tcu 2 2 0CIUD ,有显著性差异。两种宫内节育器各时段每百例妇女粗累积事件率、净累积继续使用率无显著性差异。除脱落率较高外 ,妊娠率、因症取出率较低 ,有较好的可接受性。结论　产褥期末放置MLcu 375IUD和Tcu2 2 0CIUD是安全和可行的 Objective To investigate the contraceptive efficacy, feasibility and acceptability of two copper-loaded intrauterine devices (MLcu 375IUD and Tcu 2 20CIUD) placed at the end of puerperium. Methods A prospective, randomized, clinical comparative study was used. The cumulative event rate and net cumulative continuous use rate were determined by Lifetable method. The type of bleeding was analyzed by 90-day reference period. Results in the end of the puerperium placement of two copper-loaded IUD without uterine perforation, no infection, no bleeding after placement. Adverse reactions were low after the two IUDs were placed, and the MLcu 375 IUDs at 3, 6, and 9 months were lower than that of Tcu 2 0 0 CIUDs, with significant differences. There was no significant difference in the cumulative incidence of the cumulative incidence of net cumulative use of every 100 women in each of the two types of IUD. In addition to the higher rate of shedding, the pregnancy rate, due to the lower rate of disease, there is a better acceptability. Conclusion It is safe and feasible to place MLcu 375IUD and Tcu220CIUD at the end of puerperium