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[目的]观察艾迪注射液联合长春瑞滨+顺铂化疗与单纯化疗治疗非小细胞肺癌的疗效、不良反应及其对免疫功能的影响。[方法]将经病理确诊的非小细胞肺癌60例分为两组,对照组30例采用长春瑞滨+顺铂(NP方案)化疗,治疗组30例在上述化疗方案的基础上加用艾迪注射液50ml溶于5葡萄糖水250ml静脉滴注,连用10~14d,21d为一周期,连续化疗2周期评价疗效。[结果]治疗组的临床获益率、外周血白细胞、血小板降低程度明显优于对照组(P﹤0.05),治疗组免疫功能的改变均低于对照组(P﹤0.05)治疗组的生活质量、KPS评分高于对照组(P﹤0.05)。[结论]艾迪注射液辅助肿瘤化疗有减毒增效作用,可提高机体的免疫功能和改善生活质量。
[Objective] To observe the curative effect, adverse reactions and immune function of Aidi injection combined with vinorelbine + cisplatin chemotherapy and chemotherapy alone in non-small cell lung cancer. [Methods] 60 cases of non-small cell lung cancer diagnosed by pathology were divided into two groups. 30 cases in the control group were treated with vinorelbine + cisplatin (NP regimen), and 30 cases in the treatment group were treated with the chemotherapy regimen Di injection 50ml dissolved in 250ml of dextrose in 250ml intravenous drip, once every 10 ~ 14d, 21d for a cycle of continuous chemotherapy for 2 cycles to evaluate the effect. [Results] The clinical benefit rate, peripheral white blood cells and thrombocytopenia in the treatment group were significantly better than those in the control group (P <0.05). The changes of immune function in the treatment group were lower than those in the control group (P <0.05) , KPS score higher than the control group (P <0.05). [Conclusion] Aidi injection assisted tumor chemotherapy with attenuated and synergistic effects, which can improve the body ’s immune function and improve the quality of life.