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[目的 ]研究罗红霉素干混悬剂体外抗菌作用及体内保护作用 .[方法 ]测定最小抑菌浓度、最小杀菌浓度及ED50 .[结果 ]罗红霉素对多数革兰氏阴性菌有较好的抑菌作用 ,对金黄色葡萄球菌、链球菌、表皮葡萄球菌、流感杆菌的MIC50 分别为 0 .78,0 .78,1.5 6 ,1.5 6mg/L ,MIC90 分别为 6 .2 5 ,12 .5 0 ,6 .2 5 ,12 .5 0mg/L .对金黄色葡萄菌ED50 为 116 .9mg/kg ,对照药罗力得干混悬剂ED50 为 10 9.8mg/kg ;对流感杆菌ED50 分别为 5 5 .7mg/kg和 5 1.9mg/kg .[结论 ]罗红霉素干混悬剂与同类进口药罗力得干混悬剂体外抗菌实验及体内保护实验结果无显著差异 .
[Objective] To study the antibacterial effect and in vivo protective effect of roxithromycin dry suspension in vitro. [Method] The minimum inhibitory concentration, minimum bactericidal concentration and ED50 were determined. [Results] Roxithromycin was effective against most Gram- Better antibacterial activity against Staphylococcus aureus, Streptococcus, Staphylococcus epidermidis, and Influenza bacilli MIC50 were 0.78, 0.78, 1.56, 1.56mg / L, MIC90 were 6.52, 12.55, 6.52, 12.55 mg / L. Staphylococcus aureus ED50 was 116 .9 mg / kg, the control drug Luo Li was dry suspension ED50 10 9.8 mg / kg; against influenza bacilli ED50 were 57.7 mg / kg and 51.9 mg / kg, respectively. [Conclusion] The antibacterial and in vivo protective effects of roxithromycin suspension and the similar imported LuoLiDadang suspension have no significant difference.