目的对头孢菌素引起的双硫仑样反应进行分析以引起临床医师对此反应的重视。方法对本院急诊科2006年1月至2007年12月期间应用头孢菌素类药物过程中饮酒导致双硫仑样反应的23例患者进行回顾性分析。结果23例患者均出现不同程度的双硫仑样反应,表现为颜面潮红、头痛、恶心、呕吐、心悸、胸闷、心动过速、呼吸困难等,给予补液、对症治疗后,症状于3～6h缓解,24h消失。结论应用头孢菌素类药物期间及停药一周内要禁酒,以免发生双硫仑样反应。 Objective To analyze the disulfiram-like reaction caused by cephalosporins to arouse the attention of clinicians. Methods A retrospective analysis was performed on 23 cases of disulfiram-like reactions caused by drinking during the course of cephalosporins during the period from January 2006 to December 2007 in our emergency department. Results All the 23 patients presented with different degrees of disulfiram-like reaction, showing facial flushing, headache, nausea, vomiting, heart palpitations, chest tightness, tachycardia, dyspnea, etc., given rehydration, symptomatic treatment, the symptoms in 3 ~ 6h Alleviate, 24h disappear. Conclusions The cephalosporins should be banned during the course of withdrawal and within one week of withdrawal, so as to avoid disulfiram-like reaction.