作者报告2例联合使用洛伐他汀(lovastatin)和考来烯胺(cholestyramine)后出现横纹肌溶解的病例。病例1 患者男,31岁,运动员。因Ⅱa型高脂血症使用洛伐他汀20 mg,2次/d和考来烯胺12 g,2次/d。4周后,病人肌肉弥漫性疼痛,并感全身无力,不能行走。临床检查显示腱反射迟钝以及肌肉弥漫性触痛。尿呈红棕色,纤维素试纸测试有高浓度的血红素。尿显微镜下有4～8个红细胞/HP,尿中肌红蛋白浓度为125mg/L,血清肌酶浓度升高,血清肌红蛋向>200μg/L,病人肾功能尚 The authors report two cases of rhabdomyolysis combined with lovastatin and cholestyramine. Case 1 Patient Male, 31 years old, athlete. Lovastatin 20 mg twice daily and cholestyramine 12 g twice daily for type IIa hyperlipidemia. After 4 weeks, the patient had diffuse pain in his muscles and was feeling weak and unable to walk. Clinical examination revealed slow tendon reflexes and diffuse tenderness in the muscles. Urine was reddish brown, cellulose test strips tested with high concentrations of heme. There are 4 to 8 red blood cells / HP under the urine microscope, the concentration of myoglobin in the urine is 125mg / L, serum creatinine concentration is elevated, serum myoglobin is> 200μg / L, renal function is still