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目的探讨米非司酮、米索前列醇和己烯雌酚口服和配伍利凡诺尔羊膜腔穿刺引产术用于终止16～36周妊娠的疗效。方法选择要求终止妊娠的健康妇女128例,随机分成2组,观察组64例饭后1h口服己烯雌酚片5mg,每日2次,连服3d;同时米非司酮150mg口服,早7:001次,连用2d,服药前后2h内禁食;于2药服用第3天早7:00空腹口服米索前列醇600μg,1h后羊膜腔内注入利凡诺尔80～100mg。对照组64例羊膜腔内注入利凡诺尔80～100mg。观察2组流产效果。结果观察组完全流产率高达87.5%,明显高于对照组(P<0.05);胎儿胎盘排出时间及产后24h内阴道流血量均低于对照组〔(7.40±2.87)vs(42.80±34.98)h,(94.50±33.70)vs(197.00±27.28)ml,P均<0.05〕。结论米非司酮、米索前列醇和己烯雌酚口服和配伍利凡诺尔羊膜腔穿刺引产术终止中晚期妊娠并发症少,效果显著,值得临床应用与推广。
Objective To investigate the curative effect of mifepristone, misoprostol and diethylstilbestrol administered orally and compatible with rivanol amniocentesis for terminating 16- to 36-week gestation. Methods A total of 128 healthy women who requested termination of pregnancy were randomly divided into 2 groups. 64 patients in the observation group were given oral diethylstilbestrol 5 mg 1h after meal, twice a day for 3 days. At the same time, mifepristone 150mg was orally administered as early as 7:00 , Used in conjunction 2d, fasting within 2h before taking medicine; taking 2 doses of misoprostol 600μg on the 3rd day as fasting on the 3rd day, 1 hour after the amniotic infusion of rivanol 80 ~ 100mg. The control group, 64 cases of amniotic cavity infusion rivanol 80 ~ 100mg. Observation of two groups of abortion results. Results The rate of complete abortion in the observation group was 87.5%, significantly higher than that in the control group (P <0.05). The time of placenta discharge and intravaginal bleeding within 24h after birth were significantly lower than those in the control group (7.40 ± 2.87 vs 42.80 ± 34.98 h , (94.50 ± 33.70) vs (197.00 ± 27.28) ml, all P <0.05〕. Conclusions Mifepristone, misoprostol and diethylstilbestrol oral and compatibility rivanol amniocentesis termination of late pregnancy less complications, the effect is significant, it is worthy of clinical application and promotion.