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目的:探讨妊娠期糖尿病(GDM)孕妇择期分娩前胎肺成熟度测定的临床价值。方法:共纳入52例妊娠期糖尿病孕妇,根据患者的血糖控制情况分为A组(血糖满意组)及B组(血糖不满意组),同时随机抽取20例相同孕周的正常妊娠孕妇作为对照组(C组)。所有受试者均于终止妊娠前行羊水泡沫试验,比较3组胎儿肺成熟度及新生儿呼吸窘迫综合征的发生率。结果:3组孕妇胎肺成熟分别为87.5%、65.0%、90.0%,其中B组胎肺成熟例数与A、C组比较差异有统计学意义(P<0.05),A与C组胎肺成熟例数比较差异无统计学意义(P>0.05)。随访观察均未见3组新生儿急性呼吸窘迫综合征的发生。结论:对GDM孕妇需严格控制其血糖水平,对血糖水平控制不理想者可以在择期分娩前进行羊膜腔穿刺测定胎肺成熟度,同时给予地塞米松羊膜腔注射以促胎肺成熟,进而减少新生儿呼吸窘迫综合征的发生。
Objective: To investigate the clinical value of fetal lung maturity before gestational diabetes mellitus (GDM). Methods: A total of 52 pregnant women with gestational diabetes mellitus were enrolled and divided into group A (group with satisfactory blood glucose) and group B (group with not satisfied with blood glucose) according to their glycemic control. At the same time, 20 pregnant women of the same gestational age Group (Group C). All subjects underwent amniotic fluid foam test before termination of pregnancy, and compared the incidence of fetal lung maturity and neonatal respiratory distress syndrome in the three groups. Results: The fetal lung maturation in 87 pregnant women was 87.5%, 65.0% and 90.0% respectively, in which the number of fetal lung maturity in group B was significantly different from that in group A and C (P <0.05) The number of mature cases was no significant difference (P> 0.05). No follow-up observed in 3 neonatal acute respiratory distress syndrome. Conclusion: GDM pregnant women need to strictly control their blood glucose levels, blood sugar levels are not controlled by ideal for selective delivery before amniocentesis for determination of fetal lung maturity, while dexamethasone amniotic cavity injection to promote fetal lung maturation, and thus reduce Neonatal respiratory distress syndrome.