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对12条开胸狗冠状动脉前降支安放自制可调缩窄器,形成不同程度狭窄,获得左心室收缩压力(LVSP)和dp/dt等在临界狭窄时开始显著降低(P<0.05)。CO和SV在重度狭窄时分别降低了16％和20.6％(P均<0.01)。瞬时血流速率(dQ/dt)在轻度狭窄时降低7％,重度狭窄时降低19.4％(P<0.01)。二维信号环Q-dQ/dt面积在轻度狭窄时为对照组的89.47％(P<0.05),在临界和重度狭窄时分别为对照组的80.87％和62.14％(P均<0.01)。提示冠脉不同程度的狭窄可导致心功能及收缩性不同程度受损。
The diameter of left ventricular systolic pressure (LVSP), dp / dt and so on began to decrease significantly (P <0.05) at the time of critical stenosis. CO and SV decreased by 16% and 20.6%, respectively, in patients with severe stenosis (all P <0.01). The transient blood flow rate (dQ / dt) decreased by 7% in mild stenosis and by 19.4% in severe stenosis (P <0.01). The Q-dQ / dt area of the two-dimensional signal ring was 89.47% (P <0.05) of the control group in mild stenosis and 80.87% and 62.14% of the control group in the critical and severe stenosis group (all P <0.01). Tip Different degrees of coronary stenosis can lead to varying degrees of impaired cardiac function and contractility.