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近年来,慢性苯中毒引起的再生障碍性贫血(简称“再障”),时有报道。据调查,某制鞋厂接触苯的女工,检出慢性苯中毒——再生障碍性贫血的五名,其中三名已妊娠7个月以上。而且病情严重,但终止妊娠以后,病情迅速好转。一般认为,正常妇女在妊娠期,骨髓的红细胞呈中度增生状态,妊娠末期可有25%的人程度不同的贫血,但罹患再障的确极为少见。但孕妇造血系统较活跃,苯在人体的代谢产物对骨髓细胞的毒性作用更为明显,抑制细胞分裂,影响造血功能。再则由于孕妇激素水平的改变,影响了苯的氧化、还原、水解、结合等代谢过程,使毒物不易被人体解
In recent years, chronic benzene poisoning caused by aplastic anemia (referred to as “aplastic anemia ”), have been reported. According to the survey, a shoe factory workers exposed to benzene, detected a chronic benzene poisoning - aplastic anemia five, three of whom have been more than 7 months of pregnancy. And a serious condition, but the termination of pregnancy, the condition improved rapidly. Generally believed that normal women during pregnancy, bone marrow erythrocytes was moderately proliferative state, end of pregnancy can have different degrees of anemia, 25%, but suffering from aplastic anemia is indeed extremely rare. However, pregnant women more active hematopoietic system, benzene in the human body metabolites of bone marrow toxicity is more obvious, inhibit cell division, affecting hematopoietic function. Furthermore, due to changes in hormone levels of pregnant women, benzene oxidation, reduction, hydrolysis, binding and other metabolic processes, so that the poison is not easy to be human solution