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心肌肥厚是指心肌细胞体积增大和间质增生。许多心血管疾病如高血压、心肌梗死、心脏瓣膜病、心肌病,心肌肥厚为其共同的病理阶段,研究心肌肥厚发生发展,予以早期干预、逆转肥厚,具有重要的意义。Ca2+是细胞信号转导过程中主要的第二信使,高血压时许多胞外信号可激活蛋白激酶A[
Cardiac hypertrophy refers to myocardial cell volume and interstitial hyperplasia. Many cardiovascular diseases such as hypertension, myocardial infarction, valvular heart disease, cardiomyopathy and cardiac hypertrophy are their common pathological stages. It is of great significance to study the occurrence and development of cardiac hypertrophy, to make early intervention and to reverse the hypertrophy. Ca2 + is the major second messenger in cellular signal transduction and many extracellular signals activate protein kinase A during hypertension [