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Tiotidine(下简称TD)系—有效的组胺H_2受体拮抗剂,其抑制胃酸分泌作用比甲氰咪胍(下简称CD)强且持久。本文旨在研究TD和CD的药代和药效动力学以评价TD在人体内作用持久的机制。作者选用18例无症状的慢性十二指肠溃疡病人,平均基础胃酸分泌值和五肽胃泌素(6μg/kg)引起胃酸分泌峰值,分别为9.5±3.7与49.5±8.9mM/小时。经在体胃内滴定至pH5.0测定食物引起的酸分泌值。按年龄、溃疡病程度及胃酸分泌等分组进行比较。分别口服TD或CD,测定空腹口服50、150、300mgTD与
Tiotidine (TD) is a potent histamine H 2 receptor antagonist that inhibits gastric acid secretion stronger and longer than cimetidine (CD). This article aims to study the pharmacokinetics and pharmacodynamics of TD and CD in order to evaluate the long lasting mechanism of action of TD in the human body. The authors selected 18 patients with asymptomatic chronic duodenal ulcer with mean basal gastric acid secretion and pentagastrin (6 μg / kg) causing peak gastric acid secretion of 9.5 ± 3.7 and 49.5 ± 8.9 mM / hr, respectively. Food-induced acid secretion values were determined by in vivo titration to pH 5.0. By age, ulcer disease and gastric acid secretion and other groups were compared. Oral TD or CD respectively, measured fasting oral 50,150,300 mgTD and