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肥胖是能量摄取超过能量消耗所引起的体脂沉积过多。1994年Zhang等采用克隆技术对小鼠的ob(obese)基因和人类的同源序列进行了分子克隆序列测定,开始了人类肥胖病的分子遗传学研究。ob基因产物是一种脂肪组织源激素,具有降低脂肪沉积的作用,被命名为Leptin——瘦素。 1 瘦素的结构 小鼠、大鼠和人的瘦素基因均已克隆定位,小鼠瘦素基因定位于第6号染色体,人瘦素基因位于第7号染色体长臂3区1带3亚带(7q31,3),二者均为单拷贝基因。人瘦素基因与小鼠基因相似,是一条含有167个氨基酸密码的DNA序列,长约20kb,由3个外显子和2个内含子组成。瘦
Obesity is excess body fat deposition caused by energy intake exceeding energy expenditure. In 1994, Zhang et al. Used molecular cloning sequence analysis of the mouse ob (obese) gene and human homologous sequences using cloning technology to start molecular genetic studies on human obesity. The ob gene product, an adipose tissue source hormone with a reduced fat deposition, is named Leptin - Leptin. 1 leptin structure Mouse, rat and human leptin genes have been cloned, the mouse leptin gene located on chromosome 6, the human leptin gene located on chromosome 7 long arm 3 zone 1 with 3 sub-Asian Band (7q31,3), both single copy gene. Human leptin gene and mouse gene similar to a 167 amino acid password DNA sequence, about 20kb, consists of three exons and two introns. thin