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目的:观察增液解毒颗粒干预鼻咽癌放疗所致急性口腔黏膜反应的临床疗效。方法:将60例患者随机分为2组各30例,均采用常规分割外照射治疗。治疗组予增液解毒颗粒口服和雾化吸入,对照组予庆大霉素雾化吸入,疗程均从放疗开始至放疗结束。结果:2组患者均出现不同程度的急性放射性口咽黏膜损伤,但出现口咽黏膜损伤时的放疗剂量治疗组为(23.9±4.0)Gy,对照组为(18.0±4.0)Gy,2组比较,差异有显著性意义(P<0.05)。2组患者发生放射性口咽黏膜损伤分级情况经Ridit检验,差异有显著性意义(P<0.05)。结论:增液解毒颗粒能有效防治鼻咽癌患者放疗后所致急性口腔黏膜放射性反应。
Objective: To observe the clinical effect of ZengJie Jie Duo granules on acute oral mucosal reaction induced by radiotherapy of nasopharyngeal carcinoma. Methods: 60 patients were randomly divided into two groups of 30 cases, were treated with routine external beam irradiation. The treatment group was given oral solution of oral liquid and atomized inhalation, the control group to gentamicin atomized inhalation, the course of treatment from radiotherapy to the end of radiotherapy. Results: Acute radiation-induced oropharyngeal mucosal injury occurred in both groups, but the radiation dose in the treatment group was (23.9 ± 4.0) Gy in the treatment group and (18.0 ± 4.0) Gy in the control group, compared with the control group , The difference was significant (P <0.05). Radiochemical oropharyngeal mucosal lesion grading was found by Ridit test in two groups, the difference was significant (P <0.05). Conclusion: ZengJin Jie Du particles can effectively prevent and treat nasopharyngeal carcinoma patients after radiotherapy induced acute oral mucosal radioactive reactions.