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The antifungal activity and toxicity of new type polyene macrolide antibiotics-Antifungalmycin 702 and Fungichromin against Rhizoctonia solani,Helminthosporium sigmoideum Cav. ,Magnaporthe grisea and Ustilaginoidea virens were studied by mycelial growth rate method and mycelial dry weight method in vitro. The results showed that both of Antifungalmycin 702 and Fungichromin had strong antifungal activity against four speices of rice pathogenic fungi. Treated with 50 μg / mL Antifungalmycin 702 ,the inhibitory rates of Antifungalmycin 702 against R. solani,H. sigmoideum Cav. ,M. grisea and U. virens were 100% 、 100% 、91. 20% and 68. 10% ,and EC 50 and EC 90 were 7. 00,10. 30,14. 41,26. 71 and 13. 20,17. 66,27. 67,128. 28 μg / mL,respectively. Treated with 13 μg / mL Fungichromin,the inhibitory rates of Fungichromin against four speices of rice pathogenic fungi were 78. 20% ,100% ,100% and 79. 17% ,and EC 50 and EC 90 were 1. 47,1. 91,2. 37,0. 20 and 41. 05,3. 92,4. 34,135. 54 μg / mL,respectively. The antifungal activity of Fungichromin was stronger than Antifungalmycin 702.
The antifungal activity and toxicity of new type polyene macrolide antibiotics-Antifungalmycin 702 and Fungichromin against Rhizoctonia solani, Helminthosporium sigmoideum Cav., Magnaporthe grisea and Ustilaginoidea virens were studied by mycelial growth rate method and mycelial dry weight method in vitro. The results showed that both of Antifungalmycin 702 and Fungichromin had strong antifungal activity against four speices of rice pathogenic fungi. Treated with 50 μg / mL Antifungalmycin 702, the inhibitory rates of Antifungalmycin 702 against R. solani, H. sigmoideum Cav., M. grisea and U. virens were 100%, 100%, 91.20% and 68.10%, and EC50 and EC90 were 7. 00,10. 30,14. 41,26. 71 and 13. 20,17. 66,27. 67,128. 28 μg / mL, respectively. Treated with 13 μg / mL Fungichromin, the inhibitory rates of Fungichromin against four speices of rice pathogenic fungi were 78. 20%, 100%, 100% and 79.17%, and EC 50 and EC 90 were 1. 47,1. 91,2. 37,0. 20 and 41. 05,3. 92,4. 34,135. 54 μg / mL, respectively. The antifungal activity of Fungichromin was stronger than Antifungalmycin 702.