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目的 评价顺铂联合长春新碱及环磷酰胺（ 以下简称ＰＶＣ方案） 治疗上皮性卵巢癌的疗效。方法 回顾性分析我科自１９８７ 年１ 月至１９９３ 年５ 月联合化疗治疗８５ 例上皮性卵巢癌的近、远期疗效。结果 ４８ 例卵巢上皮癌应用ＰＶＣ方案化疗，近期疗效（ 有效率） 为６８．７５％ ，与其他化疗方案（３７ 例，有效率为４０．５％ ）比较差异有显著性（ Ｐ＜０．０２） 。远期疗效分析，ＰＶＣ化疗方案组１、５ 年生存率分别为９１．５％ 和４１．４％ ，与其他化疗方案比较差异有显著性（ Ｐ＜ ０．０１，Ｐ＜ ０．０２） 。本组无一例因化疗副反应或其并发症死亡。结论 ＰＶＣ方案化疗是治疗卵巢上皮癌的有效方案之一。
Objective To evaluate the efficacy of cisplatin combined with vincristine and cyclophosphamide (hereinafter referred to as PVC regimen) in the treatment of epithelial ovarian cancer. Methods A retrospective analysis of our department from January 1987 to May 1993 combined chemotherapy of 85 cases of epithelial ovarian cancer in the short and long term efficacy. Results 48 cases of ovarian epithelial cancer with PVC regimen chemotherapy, the short term efficacy (effective rate) was 68.75%, compared with other chemotherapy regimens (37 cases, the effective rate was 40.5%) was significantly different (P <0.02 ). Long-term efficacy analysis, 1,5-year survival rates of PVC chemotherapy group were 91.5% and 41.4%, respectively, compared with other chemotherapy regimens were significantly different (P <0.01, P <0.02). None of this group died of chemotherapy side effects or complications. Conclusion PVC regimen is an effective treatment for ovarian cancer.