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应用细胞内生物电记录技术,于侧脑室和灌流槽内给予地塞米松,观察了大鼠大脑皮层、海马及海马脑片神经元膜电位的变化。结果如下:（1）在体实验记录的40个神经元中,有24个神经元对地塞米松呈去极化反应.平均幅值为（ 11.80±1.89)mV;有6个神经元的反应为超极化,平均幅值为（ 6.50±1.02）mV;有10个神经元无反应。（2）海马脑片实验,在所记录的7个神经元中有5个神经元对地塞米松呈去极化反应,平均幅值为（4.40±0.89）mV,未引起膜电导变化。结果表明:地塞米松对皮层及海马神经元的作用以去极化反应为主,部分神经元应为超极化。提示糖皮质激素对中枢神经元主要起兴奋作用,部分神经元产生抑制性影响。
Dexamethasone was administered intracerebroventricularly and perfused to cisplatin by intracellular bioelectrical recording technique. The changes of the membrane potential of neurons in cerebral cortex, hippocampus and hippocampus of rats were observed. The results were as follows: (1) Among 40 neurons recorded in vivo, 24 neurons depolarized dexamethasone with an average amplitude of (11.80 ± 1.89) mV; there were 6 neuronal responses For hyperpolarization, the average amplitude was (6.50 ± 1.02) mV; 10 neurons did not respond. (2) hippocampal slices, depolarization of dexamethasone was observed in 5 of the 7 neurons recorded, with an average amplitude of (4.40 ± 0.89) mV and no change of membrane conductance. The results showed that dexamethasone exerted a depolarization effect on cortical and hippocampal neurons, and some neurons should be hyperpolarized. Suggest that glucocorticoid is mainly excited by central neurons, some neurons have inhibitory effects.