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目的:探讨P21CIP1/ WAF1在食管癌中的表达状况及临床意义。方法:运用免疫组化技术(SP法)检测了P21CIP1 / WAF1在38例食管癌中的表达。结果:P21CIP1/ WAF1在食管癌中表达率为50% ,与正常对照差异有显著性(P<0.05)。P21 CIP1/WAF1表达与食管癌分化程度(P<0.05)、病理分期(P<0.005)和淋巴结转移(P<0.005)有关,而与年龄、性别、肿瘤大小、病理类型、肿瘤浸润深度无关(P >0.05)。结论:食管癌中P21CIP1/ WAF1低表达预示食管癌的进展和高度恶性倾向。
Objective: To investigate the expression and clinical significance of P21CIP1/WAF1 in esophageal cancer. Methods: The expression of P21CIP1/WAF1 in 38 cases of esophageal cancer was detected by immunohistochemical technique (SP method). Results: The expression rate of P21CIP1/WAF1 in esophageal cancer was 50%, which was significantly different from that of normal controls (P<0.05). The expression of P21 CIP1/WAF1 was related to the degree of differentiation of esophageal cancer (P<0.05), pathological stage (P<0.005) and lymph node metastasis (P<0.005), but not related to age, gender, tumor size, pathological type, and depth of tumor invasion ( P > 0.05). Conclusion: The low expression of P21CIP1/WAF1 in esophageal cancer predicts the progression and high-grade tendency of esophageal cancer.