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为观察国产风疹疫苗的免疫效果 ,在两个乡抽取 2 35名 2～ 39岁的健康人接种国产BRDⅡ株风疹疫苗 ,并对其中的 2 2 0人在免疫前和免疫后 1个月及 1、2、3年采血 ,用半对数回归酶联免疫吸附试验 (ELISA)检测风疹抗体 ,观察疫苗的免疫成功率及免疫持久性。结果表明 :该疫苗的免疫成功率为 5 1 4 %,免疫后 1月血清抗体阳转率为99 5 %,几何平均滴度 (GMT)为 1∶10 1 37;免疫后 3年血清抗体阳性率为 94 3%,GMT为 1∶6 0 4 0 ,且接种疫苗后反应轻微。说明国产BRDⅡ株风疹疫苗不但有良好的免疫原性 ,而且安全、稳定 ,可在人群中普遍推广使用。
To observe the immune effect of domestic rubella vaccine, 2 35 healthy people aged 2 ~ 39 years were sampled from two townships to inoculate domestic BRDⅡ strain of rubella vaccine, and 220 of them were immunized before immunization and 1 month after immunization Blood was collected for 2 and 3 years. Rubella antibodies were detected by semi-logarithmic regression enzyme-linked immunosorbent assay (ELISA), and the immunization success rate and immune persistence of the vaccine were observed. The results showed that the immunization success rate of the vaccine was 51.4%, the serum antibody positive rate was 99.5% at 1 month after immunization, the geometric mean titer (GMT) was 1:10 1 37, and the serum antibody was positive at 3 years after immunization The rate was 94.3% with a GMT of 1: 600 and a slight reaction after vaccination. This shows that domestic BRD strain Ⅱ rubella vaccine not only has good immunogenicity, but also is safe and stable and can be widely used in the population.