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目的分析机械通气患者获得性肺炎与奥美拉唑使用时间的相关性。方法选择在本院重症监护室(ICU)接受机械性通气治疗的患者作为研究对象,分别接受奥美拉唑治疗3,5,7,15 d,比较各组的胃液pH值,应激性溃疡发生率,呼吸机相关性肺炎发生率,感染发生优势菌群情况,获得性肺炎与奥美拉唑使用时间的相关性情况。结论 3 d,5 d,7 d,15 d组胃液pH值分别为(1.53±0.31),(2.74±0.74),(5.21±1.23),(6.42±1.42);应激性溃疡发生率分别为16.67%,13.33%,10.00%,3.33%;呼吸机相关肺炎发生率分别为26.67%,33.33%,40.00%,46.67%;呼吸机相关性肺炎与应激性溃疡优势菌群符合率高达50%。结论奥美拉唑使用时间与胃液pH值、呼吸机相关性肺炎发生例数呈正相关,与应激性溃疡发生例数呈负相关。
Objective To analyze the correlation between acquired pneumonia in patients with mechanical ventilation and omeprazole use time. Methods Patients in our hospital intensive care unit (ICU) undergoing mechanical ventilation were enrolled as study subjects, receiving omeprazole for 3, 5, 7 and 15 days respectively. The gastric pH, stress ulcer Incidence, the incidence of ventilator-associated pneumonia, prevalence of infection in flora, acquired pneumonia and omeprazole use of time-related situation. Conclusions The pH values of gastric juice in 3 d, 5 d, 7 d and 15 d groups were (1.53 ± 0.31), (2.74 ± 0.74), (5.21 ± 1.23) and (6.42 ± 1.42), respectively. The incidences of stress ulcer were The incidence rates of ventilator-associated pneumonia were 26.67%, 33.33%, 40.00% and 46.67% respectively. The coincidence rates of ventilator-associated pneumonia and stress ulcer dominant bacteria were as high as 50% . Conclusion The omeprazole use time was positively correlated with the pH value of gastric juice and the number of ventilator - associated pneumonia cases, and negatively correlated with the number of cases of stress ulcer.