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高原地区缺氧低压等因素,易引起高原病的发生。高原病发生机制复杂,近年来研究热点多集中在对氧自由基的研究。高原缺氧环境下,能量代谢障碍、紫外线辐射量增加等因素导致机体氧化和抗氧化失衡,氧自由基增多。过多的氧自由基又可损伤生物膜,引起蛋白质变性和DNA突变,甚至干扰细胞信号转导,引起细胞凋亡,影响组织细胞功能,最终引起高原病的发生。因此,氧自由基可能是引起高原病发生的重要中介因素,研究氧自由基与高原病的关系,可为今后高原病的防治工作提供新思路。
High altitude hypoxia and other factors, easily lead to the occurrence of altitude sickness. The pathogenesis of altitude sickness is complex. In recent years, the research focuses mostly on the study of oxygen free radicals. High altitude anaerobic environment, energy metabolism disorders, increased ultraviolet radiation and other factors lead to the body oxidation and antioxidant imbalance, increased oxygen free radicals. Excessive oxygen free radicals can damage the biofilm, causing protein denaturation and DNA mutations, or even interfere with cell signal transduction, causing apoptosis, affecting the function of tissue cells, and ultimately lead to the occurrence of altitude sickness. Therefore, oxygen free radicals may be an important mediating factor in the pathogenesis of altitude sickness. Studying the relationship between oxygen free radicals and altitude sickness may provide new ideas for prevention and treatment of altitude sickness in the future.