钩端螺旋体病是一种在世界范围内传播的重要的人兽共患病。钩端螺旋体(钩体)感染机体后,固有免疫在早期控制感染扩散中的作用及意义逐渐受到重视。巨噬细胞对钩体具有吞噬和杀伤作用,同时,致病性钩体可逃避巨噬细胞杀伤。中性粒细胞、补体系统和细胞因子在抵御钩体感染方面也具有一定的作用。 Leptospirosis is an important zoonosis that spread throughout the world. After Leptospira (Leptospira) infection of the body, the role of innate immunity in early control of spread of infection and its significance is gradually receiving attention. Macrophages phagocytose and kill the hook body, meanwhile, the pathogenic hook body can escape macrophage killing. Neutrophils, complement systems, and cytokines also play a role in fighting leptospirosis.