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目的分析Lauren分型对胃癌术后患者预后的影响。方法回顾性分析650例行胃癌根治术患者的临床资料,单因素及多因素分析影响预后的因素,分析Lauren分型中肠型、混合型、弥漫型胃癌患者的生存函数。结果单因素分析结果显示肿瘤直径、Lauren分型、T分期、N分期、TNM分期和肿瘤部位与预后有关;多因素分析结果显示肿瘤直径和T分期、N分期、TNM分期及肿瘤部位是影响患者预后的独立因素;肠型胃癌患者的生存函数与TNM分期相关,而弥漫型胃癌Ⅱ期、Ⅲ期、Ⅳ期患者生存差异无统计学意义(P>0.05)。结论 Lauren分型与胃癌患者的预后相关,虽不是影响预后的独立因素,但对患者治疗策略制订有指导意义。
Objective To analyze the effect of Lauren’s classification on the prognosis of patients with gastric cancer. Methods The clinical data of 650 patients undergoing radical gastrectomy were retrospectively analyzed. The factors influencing prognosis were analyzed by univariate and multivariate analysis, and the survival function of patients with Lauren ’s classification of midgut, mixed and diffuse gastric cancer was analyzed. Results The results of univariate analysis showed that tumor diameter, Lauren classification, T stage, N stage, TNM stage and tumor location were correlated with prognosis. Multivariate analysis showed that tumor diameter, T stage, N stage, TNM stage and tumor site There were no significant differences in survival between patients with stage II, stage III, and stage IV of diffuse type gastric cancer (P> 0.05). Conclusion Lauren’s classification is related to the prognosis of patients with gastric cancer, although it is not an independent factor affecting the prognosis, but it has guiding significance for the formulation of treatment strategies.