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目的介绍胃碰撞瘤的组织学特点和临床表现,以提高对本病的认识。方法分析1例胃腺癌与淋巴瘤伴胃肠道间质瘤碰撞瘤的临床表现,且进行组织学及免疫组织化学标记研究,并复习相关文献。结果患者主要表现为吞咽困难。在全胃切除标本中,同一肿瘤内可见中分化管状腺癌和弥漫性大B细胞性淋巴瘤呈浸润性生长,两种成分界限清楚、彼此靠近、互相融合,胃肠道间质瘤孤立胃壁病灶,三者形成碰撞瘤。腺癌表达上皮性标记物,而淋巴瘤表达B细胞抗体,胃肠道间质瘤CD34、CD117、DOG-1(+)。结论胃碰撞瘤十分罕见。胃腺癌与淋巴瘤伴胃肠道间质瘤的碰撞瘤,代表了3种独立成分彼此碰撞。临床需要提高认识,识别这类罕见肿瘤,并根据不同成分制定合适的治疗方案。
Objective To introduce histological features and clinical manifestations of gastric tumor in order to improve the understanding of this disease. Methods One case of gastric adenocarcinoma and lymphoma with gastrointestinal stromal tumors was analyzed. Histological and immunohistochemical studies were performed on the specimens and the related literatures were reviewed. Results The main manifestation of patients with dysphagia. In the total gastrectomy specimens, the same tumor can be seen in the differentiated tubular adenocarcinoma and diffuse large B-cell lymphoma was invasive growth, the two components clearly defined, close to each other, mutual fusion, gastrointestinal stromal tumor isolated stomach Lesions, the formation of three collision tumor. Adenocarcinomas express epithelial markers, whereas lymphoma express B-cell antibodies, gastrointestinal stromal tumors CD34, CD117, DOG-1 (+). Conclusion Stomach collision tumor is very rare. Gastric adenocarcinoma and lymphoma with gastrointestinal stromal tumor collisions, representing the three independent components collide with each other. Clinical needs to raise awareness, identify such rare tumors, and according to different ingredients to develop appropriate treatment.