目的　探讨P 糖蛋白 (P gp)和胎盘型谷胱甘肽 S 转移酶 (GST π)在胃腺癌中表达与临床意义。方法　应用免疫组织化学技术 ,检测 86例胃腺癌中P gp和GST π多药耐药的表达。 结果　 86例胃腺癌中P gp和GST π表达的阳性标记与胃腺癌临床化疗的相关性。 结论　P gp和GST π联合表达与胃腺癌化疗密切相关 ,检测P gp和GST π对胃腺癌化疗方案的制定具有重要的意义。 Objective To investigate the expression of P gp and GST π in gastric adenocarcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of P gp and GST π in 86 gastric adenocarcinoma. Results 86 cases of gastric adenocarcinoma of P gp and GST π expression of positive markers and gastric adenocarcinoma clinical chemotherapy. Conclusions The combined expression of P gp and GST π is closely related to the chemotherapy of gastric adenocarcinoma. Detection of P gp and GST π is of great significance for the development of chemotherapy regimens for gastric adenocarcinoma.