研究表明，内源性苯二氮革和｝氨基丁酸可能与肝性脑病的发病有关，而苯二氮草枯抗剂——氟马西尼（numazenu）有助于治疗肝性脑病。为评估本品对肝硬化伴重度肝性脑病患者的疗效，作者等对527例病理证实的肝硬化伴皿和wa级肝性脑病（HE）患者进行为期5年以上的双盲对照交叉研? Studies have shown that endogenous benzodiazepine and} aminobutyric acid may be involved in the pathogenesis of hepatic encephalopathy, whereas benzodiazepin, the flumazidine inhibitor numazenu, may help treat hepatic encephalopathy. To evaluate the efficacy of this product in patients with cirrhosis and severe hepatic encephalopathy, the authors conducted a double-blind, controlled crossover study of 527 patients with pathologically confirmed liver cirrhosis and grade wa hepatic encephalopathy (HE) for more than 5 years.