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在细胞色素P—450单加氧酶的模拟体系中,改变第五配体能极大地改变模拟体系的催化性能。张岱山、吴越发现以磺化酞菁铁(FeTSPc)为催化剂羟化苯时有FeTSPc—AsH_2—O_2三元络合物生成。抗坏血酸不仅是一个电子供体,而且还起到第五配体的作用。H.Sakurai等人提出了由氯化血红素—半胱氨酸组成的模拟体系,并认为在生物化学上具有重大意义的含硫氨基酸—半胱氨酸既是电子供体又是很好的第五配体。我们以半胱氨酸为第五配体,研究了含FePc的模拟体系对苯胺的羟化反应,并提出了相应的反应机理。
In the simulation system of cytochrome P-450 monooxygenase, changing the fifth ligand can greatly change the catalytic performance of the simulated system. Zhang Daishan and Wu Yue found that FeTSPc-AsH 2 O 2 ternary complex was formed when hydroxybenzene was hydroxylated with iron phthalocyanine (FeTSPc). Ascorbate is not only an electron donor, but also functions as a fifth ligand. H. Sakurai et al. Proposed a simulation system composed of hemin-cysteine, and considered that the biochemically significant sulfur-containing amino acid-cysteine is both an electron donor and a Five ligands. With cysteine as the fifth ligand, we studied the hydroxylation of aniline with the analog system containing FePc and proposed the corresponding reaction mechanism.