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目的 研究重型肝炎患者红细胞CR1粘附活性的变化 ,探讨其与肝功能损伤严重程度的相关性。方法 采用红细胞天然免疫功能实验对 38例重型肝炎、5 8例慢性病毒性肝炎、30例正常人的红细胞CR1粘附活性进行测定 ,并与肝功能指标比较。结果 重型肝炎及慢性病毒性肝炎患者红细胞CR1粘附活性均低于正常人群 (P <0 .0 1) ,但重型肝炎患者红细胞CR1粘附活性下降的程度显著重于慢性病毒性肝炎患者 (P <0 .0 1) ;在疾病恢复期红细胞CR1粘附活性则明显回升 ;重型肝炎患者红细胞CR1粘附活性的变化与CHE、PT及PTA等指标的变化密切相关。结论 重型肝炎患者红细胞CR1粘附活性的变化与肝功能损伤严重程度密切相关 ,该项可作为分析重型肝炎患者病情严重程度、判断病情发展及预后的重要参考指标。
Objective To study the changes of adhesion activity of erythrocyte CR1 in patients with severe hepatitis and to explore its correlation with the severity of liver injury. Methods The erythrocyte CR1 adhesion activity of 38 cases of severe hepatitis, 58 cases of chronic viral hepatitis and 30 cases of normal people were determined by innate immune function test of erythrocytes, and compared with the indexes of liver function. Results The adhesion activity of erythrocyte CR1 in patients with severe hepatitis and chronic viral hepatitis was lower than that in normal people (P <0.01). However, the adhesion activity of erythrocyte CR1 in patients with severe hepatitis was significantly lower than that in patients with chronic viral hepatitis .0 1). The adhesion activity of erythrocyte CR1 increased significantly during the convalescent phase of disease. The change of adhesion activity of erythrocyte CR1 in patients with severe hepatitis was closely related to the changes of CHE, PT and PTA. Conclusion The changes of CR1 adhesion activity of erythrocyte in severe hepatitis patients are closely related to the severity of liver injury, which can be used as an important reference index for analyzing the severity of severe hepatitis patients and judging the progression and prognosis of severe hepatitis patients.