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目的 探讨中老年男性长期服用小剂量阿司匹林 (ASA)预防缺血性脑卒中 (IS)的临床价值。方法 对 40 2 0例中老年男性研究对象采用ASA连续干预 10年并与 3195 0例男性同年龄组的自然人群对照 ,观察 10年IS的发病、死亡等相关问题。结果 ASA干预 9年后IS发病率下降 43.89% ,死亡率下降37.33% ,而ASA未使出血性脑卒中 (HS)发病率及死亡率增加。结论 长期服用小剂量ASA预防IS是有效的 ,并无明显胃肠毒性反应 ,且不增加HS的危险性
Objective To investigate the clinical value of long-term aspirin (ASA) for prevention of ischemic stroke (IS) in middle-aged and elderly men. Methods A total of 40 20 middle-aged and elderly male subjects were treated with ASA for 10 years and compared with 3195 0-year-old men in the same age group. The incidence, mortality and other related problems of 10-year IS were observed. Results After ASA intervention for 9 years, the incidence of IS decreased by 43.89% and the mortality rate decreased by 37.33%. ASA did not increase the incidence of hemorrhagic stroke (HS) and mortality. Conclusion Long-term use of low dose ASA is effective in preventing IS without obvious gastrointestinal toxicity and does not increase the risk of HS