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Angew.Chem.Int.Ed.2015,54,272~275醚类化合物广泛分布于天然产物及具有生理活性的医药化合物中,相对于传统的乌尔曼交叉偶联反应,C—H的烷氧基化是最有效和简单的构筑C—O键的方法之一.目前C—H键的直接烷基化的催化策略集中在钯和铜催化剂,但在底物的范围和催化体系的适用性等方面具有很大的局限性.郑州大学化学与分子工程学院宋毛平课题组利用廉价易得的、易引入和离去的2-氨基吡啶氮氧化物为导向基团,在温和条件下实现
Angew.Chem.Int.Ed.2015,54,272 ~ 275 ether compounds are widely distributed in natural products and physiologically active pharmaceutical compounds, compared to the traditional Ullmann cross-coupling reaction, C-H alkoxylation Is one of the most effective and simple ways to construct C-O bonds.Currently the catalytic strategy of direct alkylation of C-H bonds is focused on palladium and copper catalysts, but in the range of the substrate and the applicability of the catalytic system Has great limitations.Zhengzhou University School of Chemistry and Molecular Engineering Song Mao-ping group using cheap, easy introduction and departure of 2-aminopyridine nitrogen oxides as a guide group, achieved under mild conditions