论文部分内容阅读
目的观察急性缺血性脑卒中不同病因学亚型患者不同时期血清C-反应蛋白水平的动态变化。方法选择急性缺血性脑卒中患者150例,按照TOAST分型分为5个亚型组。所有入组者于发病1周内及3个月后行血清超敏C-反应蛋白浓度测定。结果所有急性缺血性脑卒中患者在不同时期血清超敏C-反应蛋白浓度均较健康对照组明显增高[1周之内为(53.4±25.6)mg/L,3个月后为(25.2±9.2)mg/L)]。在5个病因学亚型组中,心源性脑栓塞组1周之内的血清超敏C-反应蛋白浓度较其他亚型组高[(77.4±20.6)mg/L)],其次为大动脉粥样硬化性卒中组[(61.5±25.6)mg/L]。在随后3个月大动脉粥样硬化性卒中组血清超敏C-反应蛋白的浓度明显高于其他亚型组[(30.8±6.7)mg/L]。结论发生缺血性脑卒中3个月后大动脉粥样硬化性卒中组血清C-反应蛋白仍呈持续性增高,提示动脉粥样硬化炎症的持续存在。
Objective To observe the dynamic changes of serum C-reactive protein at different stages in patients with different etiology subtypes of acute ischemic stroke. Methods 150 patients with acute ischemic stroke were selected and divided into 5 subtypes according to TOAST classification. All patients were tested for serum high-sensitivity C-reactive protein within 1 week and 3 months after onset. Results All patients with acute ischemic stroke had significantly higher levels of serum C-reactive protein at different stages than those in healthy controls (53.4 ± 25.6 mg / L within 1 week, 25.2 ± 3 months after 3 months 9.2) mg / L)]. Among the five etiological subtypes, serum concentrations of C-reactive protein were significantly higher in patients with cardiogenic cerebral embolism within one week [(77.4 ± 20.6) mg / L) than those in other subtypes, followed by the aorta Atherosclerotic stroke group [(61.5 ± 25.6) mg / L]. Serum levels of hypersensitivity C-reactive protein were significantly higher in the group with atherosclerosis than in the other subgroups [(30.8 ± 6.7) mg / L] in the subsequent 3 months. Conclusions After 3 months of ischemic stroke, the level of serum C-reactive protein in patients with severe atherosclerotic stroke continues to increase, suggesting the persistence of atherosclerotic inflammation.