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目的：探讨前房穿刺联合 Nd：YAG 激光早期治疗急性闭角型青光眼发作的临床疗效。方法选取160例急性闭角型青光眼急性发作期患者，随机分为观察组和对照组，每组80例。对照组患者仅使用缩瞳剂和β-肾上腺等药物进行保守治疗，观察组对患者行前房穿刺术后，增加 Nd：YAG 激光切除术治疗。术后观察患者眼睛的视力、眼压和房角开放情况，并进行3~6个月的随访。结果观察组80例患者在术后24 h，72例（90%）患者手术眼的视力得到提升（≥2行）；术后2 h 时，患者平均眼压为（19.8±7.3）mm Hg（1 mm Hg =0.133 kPa）；术后69例（86.2%）患者手术眼的房角开放情况得到良好的改善，平均开放度数为（6.31±0.22）°。对照组80例患者患眼视力没有得到明显提升，平均眼压为（25.2±8.6）mm Hg，房角平均开放度数为（4.09±0.18）°。观察组治愈率（95%）显著高于对照组（72.5%）。结论将前房穿刺术联合 Nd：YAG 激光切除术应用于急性闭角型青光眼发作早期的治疗中，可以达到控制眼压，改善房角开放情况的目的，预后良好，值得在临床中进行推广。“,”Objective To investigate the clinical curative effect of anterior chamber puncture combined with Nd:YAG laser in the early treatment of acute angle-closure glaucoma. Methods Select 160 cases of acute angle-closure glaucoma patients with a-cute onset,and they were randomly divided into observation group and control group with 80 patients in each group. Control group was only given the reduction agent and the pupil beta adrenal drugs such as conservative treatment. In observation group, the patients with anterior room after paracentesis,added the Nd:YAG laser resection treatment. In patients with postoperative ob-servation visual acuity,intraocular pressure and open corner of the eye were observed. All of the patients with 3 to 6 months of follow-up. Results Among the 80 patients in observation group after 24 h,72 cases(90% )with eye eyesight improved(2 rows or higher);2 h after surgery,patients with the average intraocular pressure was(19. 8 ± 7. 3)mm Hg(1 mm Hg = 0. 133 kPa);the corner of the eye open was improved in 69(86. 2% )patients after surgery,average open degree was(6. 31 ± 0. 22)° in the control group,80 cases suffering from eye vision had not been improved significantly,the average intraocular pressure was(25. 2 ± 8. 6)mm Hg,average open degree of corner was(4. 09 ± 0. 18)°. The cure rate in observation group(95% )was significantly higher than that in the control group(72. 5% ). Conclusion The anterior chamber paracentesis combined with Nd:YAG laser resection is applied to the treatment of early acute angle-closure glaucoma. It can achieve control of intraocular pressure,improve the condition of open corner purpose,prognosis is good,so it is worthy popularizing in clinic.