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目的 探讨胃癌组织中多种基因变异间相互关系。方法 对 78例胃癌组织中癌基因P2 1、P185以及抑癌基因RB、P5 3、P16和nm2 3的蛋白表达结果进行SPSS和SAS的计数资料相关性分析和多因素分析。结果 P2 1和P185、RB与P16、P16与P5 3以及P16与nm2 3间存在相关关系 ;胃癌发生同时涉及 4个或 4个以上蛋白异常的情况相对少见 ;P16蛋白缺失为判断胃癌淋巴结转移的独立因素 ;P5 3基因突变和P16蛋白缺失为判断胃癌患者癌浸润深度的独立因素。结论 胃癌中不仅存在多种基因改变 ,而且它们在胃癌发生发展中可能存在协同作用 ;P16蛋白缺失为判断胃癌患者预后的最有用的指标之一。
Objective To investigate the relationship between multiple genetic variants in gastric cancer. Methods Correlation analysis and multivariate analysis of SPSS and SAS data were performed on the expression of oncogenes P2 1 and P185 and tumor suppressor genes RB, P53, P16 and nm23 in 78 cases of gastric cancer. Results There was a correlation between P2 1 and P185, RB and P16, P16 and P5 3, and P16 and nm23. The incidence of gastric cancer involving 4 or more protein abnormalities at the same time was relatively rare. The absence of P16 protein was used to determine lymph node metastasis in gastric cancer. Independent factors; P53 gene mutation and deletion of P16 protein are independent factors for judging the depth of cancer invasion in gastric cancer patients. Conclusion There are not only multiple genetic changes in gastric cancer, but also they may have synergistic effects in the development of gastric cancer. The loss of P16 protein is one of the most useful indicators to determine the prognosis of gastric cancer patients.