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目的了解结直肠癌转移相关标记物过表达对A/B期患者预后的影响。方法收集2001至2002年65例结直肠癌的石蜡标本,用免疫组化染色检测CD44V6、MMP-2、COX-2、EGF、EGFR和VEGF的表达情况。比较阳性表达组和阴性表达组之间5年复发转移率的差异和多个肿瘤标记物过表达对预后的影响。结果A/B期结直肠癌中,CD44V6、EGF和EGFR蛋白阳性组的5年复发转移率分别为30.9%、38.1%和27.5%,显著高于阴性组的5年复发转移率8.3%、8.8%和11.8%(P=0.045、0.022和0.047);有3个以上指标阳性组的5年复发转移率高于0~2个指标阳性组,而5年生存率低于0~2指标阳性组,差异均有显著性(P=0.019和0.030)。结论CD44V6、EGF和EGFR蛋白过表达与Dukes A/B期患者高复发转移相关,肿瘤转移标记物高表达越多,复发转移的机率越高,5年生存率越低。
Objective To investigate the effect of overexpression of metastasis-associated markers on the prognosis of A / B patients. Methods Sixty-five paraffin-embedded specimens of colorectal cancer were collected from 2001 to 2002. The expressions of CD44V6, MMP-2, COX-2, EGF, EGFR and VEGF were detected by immunohistochemistry. The difference of 5-year recurrence and metastasis rate and the effect of multiple tumor markers overexpression on the prognosis were compared between the positive expression group and the negative expression group. Results The 5-year recurrence and metastasis rates of CD44V6, EGF and EGFR protein positive group were 30.9%, 38.1% and 27.5% respectively in A / B colorectal cancer group, which were significantly higher than those of 5-year recurrence and metastasis in negative group % And 11.8%, respectively (P = 0.045, 0.022 and 0.047). The 5-year recurrence and metastasis rate of the positive group with more than 3 indexes was higher than that of the 0-2 index positive group, while the 5-year survival rate was lower than that of the 0-2 index positive group , The differences were significant (P = 0.019 and 0.030). Conclusion The overexpression of CD44V6, EGF and EGFR is associated with high recurrence and metastasis in patients with Dukes A / B stage. The more tumor metastasis markers are expressed, the higher the recurrence and metastasis rate is, the lower the 5-year survival rate is.