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目的评价血清高敏C-反应蛋白水平与颈动脉粥样硬化之间的关系,进一步探讨动脉粥样硬化的发生机制。方法随机选取健康体检者86例,行常规颈部血管超声检查,根据检查结果将病例分为颈动脉粥样硬化组及非颈动脉粥样硬化组。比较2组研究者之间血清高敏C-反应蛋白水平之间的差异,并探讨血清高敏C-反应蛋白水平与颈动脉中膜厚度之间的关系。结果颈动脉粥样硬化组血清高敏C-反应蛋白水平亦高于对照组,二者比较,差异有统计学意义(P<0.05)。高敏C-反应蛋白水平与动脉中膜厚度呈正相关。结论血清高敏C-反应蛋白水平与动脉硬化的形成有关,可能为缺血性脑血管病的危险因素。
Objective To evaluate the relationship between serum high-sensitivity C-reactive protein and carotid atherosclerosis and further explore the mechanism of atherosclerosis. Methods Totally 86 healthy subjects were selected randomly and underwent routine neck vascular ultrasonography. According to the results, the patients were divided into carotid atherosclerosis group and non-carotid atherosclerosis group. The difference between serum high-sensitivity C-reactive protein levels was compared between the two groups and the relationship between serum high-sensitivity C-reactive protein and carotid artery intima-media thickness was also investigated. Results The level of serum high-sensitivity C-reactive protein in carotid atherosclerosis group was also higher than that in control group. The difference was statistically significant (P <0.05). High-sensitivity C-reactive protein was positively correlated with arterial thickness. Conclusions Serum high-sensitivity C-reactive protein is associated with the formation of atherosclerosis and may be a risk factor for ischemic cerebrovascular disease.