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目的:研究EphrinB2与血管内皮生长因子(VEGF)在鼻咽癌组织中的表达情况及其与各临床病理因素之间的关系。方法:应用免疫组织化学SP法检测136例鼻咽癌组织标本及20例鼻咽黏膜慢性炎症组织中EphrinB2与VEGF的表达情况。结果:①136例鼻咽癌组织中EphrinB2与VEGF阳性率分别为63.2%和67.6%,二者的阳性表达均明显高于鼻咽黏膜慢性炎症组织(P<0.01);②EphrinB2和VEGF蛋白的阳性表达分别与淋巴结转移、脑神经麻痹、颅底侵犯和临床分期相关(P<0.01);③在鼻咽癌组织中EphrinB2的表达与VEGF的表达显著相关(P<0.01)。结论:EphrinB2和VEGF可能在鼻咽癌的浸润、转移和血管生成中起重要作用,它们之间可能存在一定的相互调控机制,它们有望成为判断鼻咽癌发生、发展、预后及指导治疗的新的生物学指标。
Objective: To investigate the expression of EphrinB2 and vascular endothelial growth factor (VEGF) in nasopharyngeal carcinoma (NPC) and its relationship with clinicopathological factors. Methods: Immunohistochemical SP method was used to detect the expression of EphrinB2 and VEGF in 136 specimens of nasopharyngeal carcinoma and 20 specimens of chronic inflammation of nasopharyngeal mucosa. Results: ① The positive rates of EphrinB2 and VEGF in 136 cases of nasopharyngeal carcinoma were 63.2% and 67.6%, respectively, which were significantly higher than those in chronic inflammation of nasopharyngeal mucosa (P <0.01); ② The positive expression of EphrinB2 and VEGF (P <0.01). (3) There was a significant correlation between the expression of EphrinB2 and the expression of VEGF in nasopharyngeal carcinoma (P <0.01). Conclusion: EphrinB2 and VEGF may play an important role in the infiltration, metastasis and angiogenesis of nasopharyngeal carcinoma. There may be some mutual regulation between them. They are expected to become new to judge the occurrence, development, prognosis and guidance of nasopharyngeal carcinoma Biological indicators.