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1.本文总结了北京、上海7个医院麦角隐亭治疗帕金森病的临床经验,国内尚未见报导。 2.观察18例,其中15例为用左旋多巴(或复方左旋多巴)治疗后发生疗效减退、症状波动者,3例未经其他治疗。共13例临床症状有不同程度改善(占72.2％)无效1例,恶化4例, 3.65岁以上病人疗效明显(P<0.01),病情较重者进步显著(P<0.01)对剂末现象有效,开——关现象无效。 4.据本文观察中国人较欧美人用量小,但仍可使多巴用量减少1/6—1/2。本药的疗效减退出现于102—154天。 5.副作用的发生,个体差异较大。服药初期、小剂量时,常见头晕、无力等副作用,剂量较大时易发生体位性低血压,严重者摔倒。治疗前、后实验室检查无明显改变。
1. This article summarizes the clinical experience of treating Parkinson’s disease with ergocryptine in 7 hospitals in Beijing and Shanghai. There is no report in China yet. Observed in 18 cases, of which 15 cases of levodopa (or compound levodopa) after treatment, the curative effect decreased, the symptoms of fluctuations, 3 cases without other treatment. A total of 13 cases showed clinically significant improvement (72.2%), 1 case was ineffective, 4 cases were deteriorated, and patients with 3.65 years old had significant curative effect (P <0.01). , On-off phenomenon is invalid. 4. According to this article, Chinese people use less than Europeans and Americans, but still can reduce the use of dopa 1 / 6-1 / 2. The drug’s efficacy decreased in 102-154 days. 5. The occurrence of side effects, individual differences. Early medication, small doses, the common dizziness, weakness and other side effects, prone to orthostatic hypotension when the dose is large, severe cases fall. Before and after treatment, no significant changes in laboratory tests.