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莲心碱5mg/kg,ⅳ可显著地对抗乌头碱诱发的大鼠及哇巴因诱发的豚鼠心律失常;也能预防肾上腺素所致的豚鼠室颤发生;还能对抗心肌缺血复灌所致的大鼠心律失常。莲心碱8mg/kg,ⅳ能使家兔心率减慢,P-R间期延长;莲心碱30μmol/L可延长离体豚鼠左房功能性不应期。结果提示,莲心碱抗实验性心律失常作用可能主要与其阻滞Ca++内流有关。
Neigentine 5 mg/kg, iv significantly against aconitine-induced rats and ouabain-induced arrhythmias in guinea pigs; it also prevented adrenergic-induced ventricular fibrillation in guinea pigs; but also against myocardial ischemia and re-irrigation Induced arrhythmias in rats. With 8 mg/kg of lotus root, iv can slow down the heart rate of rabbits and prolong the P-R interval. 30 μmol/L of lotusine can extend the left atrial functional refractory period in isolated guinea pigs. The results suggest that the anti-arrhythmic effects of lotusine on the arrhythmia may be related to its blockade of Ca++ influx.