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目的探讨硝酸甘油和多巴胺联合应用治疗老年急性左心衰的疗效。方法对64例老年急性左心衰患者静脉滴注硝酸甘油和多巴胺。治疗前、后测定平均血压(MAP)、心率(HR)、心率与收缩压乘积(HR·SBP)、血氧饱和度(SaO2)及左室射血分数(LVEF),并进行临床疗效判定。结果59例治疗后HR、MAP、HR·BP均显著降低,LVEF、SaO2显著增高(P<0.01)或恢复正常;临床总有效率为92%,无效死亡5例。结论静脉滴注硝酸甘油和多巴胺,具有改善组织灌注、减轻心脏前后负荷、迅速解除肺水肿、改善心功能和稳定血压的协同作用,是治疗老年急性左心衰的有效联合用药。
Objective To investigate the efficacy of nitroglycerin and dopamine in the treatment of senile acute left heart failure. Methods Sixty-four elderly patients with acute left heart failure were infused with nitroglycerin and dopamine. Mean blood pressure (MAP), heart rate (HR), heart rate and systolic blood pressure (HR · SBP), blood oxygen saturation (SaO2) and left ventricular ejection fraction (LVEF) were measured before and after treatment. Results The HR, MAP, HR · BP of 59 cases were significantly decreased, LVEF and SaO2 were significantly increased (P <0.01) or returned to normal after treatment. The total clinical effective rate was 92%, and 5 cases were ineffective. Conclusion Intravenous administration of nitroglycerin and dopamine has the synergistic effect of improving tissue perfusion, reducing cardiac load, rapidly relieving pulmonary edema, improving cardiac function and stabilizing blood pressure. It is an effective combination therapy for the treatment of acute left heart failure in the elderly.