论文部分内容阅读
目的制备白芍总昔PVA微囊并探讨其包封率及药物释放情况。方法采用悬浮界面交联法对不同质量浓度的PVA白芍总苷微囊的制备进行考察,并采用紫外分光光度法绘制白芍总苷在人工肠液(pH 7.4)中的标准曲线。利用紫外分光光度法测定微囊的包封率和载药量,测定优化工艺后微囊在12 h内溶出的量并作释放度考察曲线。结果通过界面交联法得到的白芍总苷微囊,干燥后平均粒径为10μm左右,其平均包封率和载药量依次为71.08%、7.32%。结论紫外分光光度法测定肠溶微囊中白芍总苷的包封率、载药量及释放方法可靠,线性良好,稳定性好,PVA微囊使包封药物白芍总苷有肠溶特性。
OBJECTIVE To prepare the total phenol-PVA microcapsules of Radix Paeoniae Alba and discuss its entrapment efficiency and drug release. Methods Suspension interfacial crosslinking method was used to study the preparation of PVA paeony glycoside microcapsules with different mass concentration. Ultraviolet spectrophotometry was used to draw the standard curve of total glucosides of Paeony in artificial intestinal juice (pH 7.4). The encapsulation efficiency and drug loading of the microcapsules were determined by ultraviolet spectrophotometry. The dissolution amount of the microcapsules within 12 h after the optimization process was determined and the release curve was investigated. Results The total glycoside microcapsules of paeoniae alba obtained by interfacial cross-linking method showed an average particle size of about 10μm after drying. The average encapsulation efficiency and drug loading were 71.08% and 7.32%, respectively. Conclusion UV-spectrophotometry determination of enteric-coated microcapsules in the encapsulation efficiency of total glucosides of paeony, drug loading and release method is reliable, good linearity, good stability, PVA microcapsules encapsulated drugs total glucosides of paeony have enteric properties .