多发性骨髓瘤伴发髓外皮肤浆细胞瘤和坏疽性脓皮病案例报道

来源 :世界核心医学期刊文摘(皮肤病学分册) | 被引量 : 0次 | 上传用户:blanknan
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
A variety of cutaneous manifestations has been described in multiple myeloma including extramedullary cutaneous plasmacytomas, cutaneous amyloidosis, pyoderma gangrenosum, leukocytoclastic vasculitis, necrobiotic xanthogranuloma, scleromyxedema, Sweet’ s syndrome, subcorneal pustular dermatosis, scleredema, and plane xanthomas etc. An 89-year-old Korean man, who had been suffering from multiple myeloma 1 year previous, presented for evaluation of two nodules on the right side of the forehead, left side of the chest (7th rib area), and multiple ulcers with papulopustules on both the thigh and the left side of the chest (2nd rib area) during 15 days, which developed at the same time. A biopsy of a lesion which manifested as a cutaneous nodule on the right side of the forehead revealed dermal infiltration by well-differentiated plasma cells, similar to those found on a bone marrow biopsy, and a biopsy of the lesion manifested as a painful ulceration on the right thigh area showing dermal neutrophilic infiltration. Histologic findings were consistent with plasmacytoma and pyoderma gangrenosum, respectively. We present a case of multiplemyeloma which developed extramedullary cutaneous plasmacytoma and pyoderma gangrenosum simultaneously, which is very rare. The patient was treated with a systemic steroid and conservative therapy. A variety of cutaneous manifestations has been described in multiple myeloma including extramedullary cutaneous plasmacytomas, cutaneous amyloidosis, pyoderma gangrenosum, leukocytoclastic vasculitis, necrobiotic xanthogranuloma, scleromyxedema, Sweet’s syndrome, subcorneal pustular dermatosis, scleredema, and plane xanthomas etc. An 89-year -old Korean man, who had been suffering from multiple myeloma 1 year previous, presented for evaluation of two nodules on the right side of the forehead, left side of the chest (7th rib area), and multiple ulcers with papulopustules on both the thigh and the left side of the chest (2nd rib area) during 15 days, which developed at the same time. A biopsy of a lesion which manifested as a cutaneous nodule on the right side of the forehead revealed dermal infiltration by well-differentiated plasma cells , similar to those found on a bone marrow biopsy, and a biopsy of the lesion manifested as a painful ulceration on the right thigh area showing dermal Histologic findings were consistent with plasmacytoma and pyoderma gangrenosum, respectively. We present a case of multiplemyeloma which developed extramedullary cutaneous plasmacytoma and pyoderma gangrenosum simultaneously, which is very rare. The patient was treated with a systemic steroid and conservative therapy.
其他文献
组蛋白乙酰化和去乙酰化在基因的转录调控中发挥着重要作用,组蛋白乙酰化水平由组蛋白乙酰化酶(HAT)和组蛋白去乙酰化酶(HDAC)的动态平衡调节。HAT和HDAC的异常与肿瘤的发生
网页中的隐性要素是不被浏览者直观看见的,借助于页面中的各种显性的视觉要素所表现出来的,版式设计就是网页中的隐性要素之一,网页设计中的版式编排,是在有限的屏幕空间里将
广东省制冷学会于三月十八日至二十日在广州市番禺县召开了“冷库中的空气渗透”小型专题学术座谈会。邀请了渐江大学、重庆建筑工程学院、湖北工业建筑设计院、广东省建筑
在全国广大《机械制造》读者、作者及有关单位的积极支持、参与下,本刊1996年度优秀读者、优秀作者经报评、推荐、筛选、评定现已揭晓。评出刘华云、施建福等优秀读者六名。
马克思当年写《资本论》的时候,尽管认为流通领域不增加商品的价值,但他强调了流通对于实现商品在市场上“惊险一跃”的重要性。然而,无论马克思怎样的加重语气,他断是不会
目的:研究雄激素应答元件陷阱DNA(AREdecoy)对前列腺特异抗原(PSA)基因启动子的抑制作用及其对前列腺癌细胞LNCaP细胞生长活性的影响,为前列腺癌的基因治疗寻求新的策略。方
近来常应用甲氰咪胍(Cimetidine)治疗食管返流,虽能改善烧心等症状,但内窥镜发现食管炎仍然存在。本文作者设计了二种鼠的实验模型:模型Ⅰ系将空肠第一段作食管-空肠吻合术,
本文报道了同时运用数种显带方法显示了一种迄今从未见过的X染色体的结构异常。女病人18岁,是一例纯性腺发育不全,原发性闭经。躯体上并无Turner综合征的典型异常。乳房稍有
2003年,我国经济克服了美伊战争引发的石油涨价、“非典”疫情及部分地区洪涝灾害带来的困难,保持了2002年以来形成的良好运行态势。表现为GDP继续快速增长、固定资产投资和
作者用夜猴体内的间日疟原虫制备的抗原,致敏醛化的红细胞。抗原的制备方法是:经肝素抗凝收集的全血用0.85%盐水洗涤3次,冲洗过的细胞悬浮在3倍体积的pH6.4的抗原稀释液中,