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目的：研究两型肠上皮化生中异型增生的发生率并探讨其在胃癌发生中的作用。方法：对我国胃癌高发区山东省临朐县３５～６４岁的居民３４０１人进行了胃内７个标准部位的胃镜活检，对所有的活检材料均进行了病理检查，并研究肠化生类型及其与异型增生的关系。结果：这一人群的肠化生检出率为５２．８％，异型增生检出率为２０．１％，小肠型肠化生中异型增生的发生率为３３．６％，大肠型肠化生中的发生率为５１％（Ｐ＜０．０１）。结论：研究表明，与小肠型化生相比较，大肠型化生更易于发生异型增生，因此，最终发生癌变的危险性可能高于小肠型化生
Objective: To study the incidence of dysplasia in two types of intestinal metaplasia and to explore its role in the development of gastric cancer. METHODS: Gastric biopsies were performed on 3 301 inhabitants in 35 to 64-year-old residents of Linyi County in Shandong Province, a high-risk area of gastric cancer in our country. Pathological examinations were performed on all biopsy materials and the types of intestinal metaplasia were studied. Relationship with dysplasia. Results: In this population, the detection rate of intestinal metaplasia was 52.8%, the detection rate of dysplasia was 20.1%, the incidence of dysplasia in intestinal metaplasia of small intestine was 33.6%, and intestinal metaplasia The incidence of birth was 51% (P < 0.01). CONCLUSIONS: Studies have shown that colonic metaplasia is more prone to dysplasia than small intestine metaplasia. Therefore, the risk of eventually developing cancer may be higher than that of small intestinal metaplasia.