目的:探讨红色诺卡氏菌细胞壁骨架（Nocardiarubracellwallskeleton，N-CWS）对膀胱肿瘤的治疗效果及免疫学机制。方法：膀胱癌荷瘤鼠注射N-CWS，观察N-CWS的抑瘤效果及N-CWS对白细胞介素2（IL-2）水平和自然杀伤（NK）细胞活性的影响。结果：注射N-CWS的膀胱癌荷瘤鼠的抑瘤率为96.2％，其IL-2水平及NK细胞活性明显高于肿瘤对照组。结论：N-CWS对膀胱癌具有明显的抑制作用，其机制可能是通过提高机体的IL-2水平和NK细胞活性促进机体的抗肿瘤免疫而实现的。 Objective: To investigate the therapeutic effect and immunological mechanism of Nocardiarca ratwallis skeletal (N-CWS) on bladder tumor. Methods: The tumor-bearing mice were injected with N-CWS to observe the antitumor effect of N-CWS and the effects of N-CWS on interleukin 2 (IL-2) and natural killer (NK) cell activity. Results: The tumor inhibition rate of bladder cancer bearing mice injected with N-CWS was 96.2%, and the level of IL-2 and the activity of NK cells were significantly higher than that of the tumor control group. Conclusion: N-CWS can significantly inhibit bladder cancer, and its mechanism may be through the body’s IL-2 level and NK cell activity to promote the body’s anti-tumor immunity to achieve.